NAD(P)H:quinone oxidoreductase 1 reduces the mutagenicity of DNA caused by NADPH:P450 reductase-activated metabolites of benzo(a)pyrene quinones.

The role of microsomal NADPH:cytochrome P450 reductase (P450 reductase) and cytosolic NAD(P)H:quinone oxidoreductase 1 (NQO1 or DT-diaphorase) in the mutagenicity of benzo(a)pyrene-3,6-quinone (BP-3,6-Q) was studied using supF tRNA gene as the mutational target. pUB3 carrying the supF tRNA gene upon...

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Detalles Bibliográficos
Autores principales: Joseph, P., Jaiswal, A. K.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1998
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2149967/
https://www.ncbi.nlm.nih.gov/pubmed/9514048

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2149967/
https://www.ncbi.nlm.nih.gov/pubmed/9514048

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