Prolonged in vivo tumour retention of a human diabody targeting the extracellular domain of human HER2/neu.

Single-chain Fv (scFv) molecules exhibit highly specific tumour-targeting properties in tumour-bearing mice. However, because of their smaller size and monovalent binding, the quantities of radiolabelled scFv retained in tumours limit their therapeutic applications. Diabodies are dimeric antibody-ba...

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Detalles Bibliográficos
Autores principales: Adams, G. P., Schier, R., McCall, A. M., Crawford, R. S., Wolf, E. J., Weiner, L. M., Marks, J. D.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1998
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150193/
https://www.ncbi.nlm.nih.gov/pubmed/9652755

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150193/
https://www.ncbi.nlm.nih.gov/pubmed/9652755

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