Mechanism of N-Wasp Activation by Cdc42 and Phosphatidylinositol 4,5-Bisphosphate

Neuronal Wiskott-Aldrich Syndrome protein (N-WASP) transmits signals from Cdc42 to the nucleation of actin filaments by Arp2/3 complex. Although full-length N-WASP is a weak activator of Arp2/3 complex, its activity can be enhanced by upstream regulators such as Cdc42 and PI(4,5)P(2). We dissected t...

Descripción completa

Detalles Bibliográficos
Autores principales: Rohatgi, Rajat, Ho, Hsin-yi Henry, Kirschner, Marc W.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2000
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150699/
https://www.ncbi.nlm.nih.gov/pubmed/10995436

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150699/
https://www.ncbi.nlm.nih.gov/pubmed/10995436

Ejemplares similares