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Role of the F-Box Protein Skp2 in Adhesion-Dependent Cell Cycle Progression

Cell adhesion to the extracellular matrix (ECM) is a requirement for proliferation that is typically lost in malignant cells. In the absence of adhesion, nontransformed cells arrest in G1 with increased levels of the cyclin-dependent kinase inhibitor p27. We have reported previously that the degrada...

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Detalles Bibliográficos
Autores principales: Carrano, Andrea C., Pagano, Michele
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150734/
https://www.ncbi.nlm.nih.gov/pubmed/11425869