Mutations in the cytoplasmic domain of P0 reveal a role for PKC-mediated phosphorylation in adhesion and myelination

Mutations in P0 (MPZ), the major myelin protein of the peripheral nervous system, cause the inherited demyelinating neuropathy Charcot-Marie-Tooth disease type 1B. P0 is a member of the immunoglobulin superfamily and functions as a homophilic adhesion molecule. We now show that point mutations in th...

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Detalles Bibliográficos
Autores principales: Xu, Wenbo, Shy, Michael, Kamholz, John, Elferink, Lisa, Xu, Gang, Lilien, Jack, Balsamo, Janne
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150845/
https://www.ncbi.nlm.nih.gov/pubmed/11673479
http://dx.doi.org/10.1083/jcb.200107114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150845/
https://www.ncbi.nlm.nih.gov/pubmed/11673479
http://dx.doi.org/10.1083/jcb.200107114

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