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VDAC-dependent permeabilization of the outer mitochondrial membrane by superoxide induces rapid and massive cytochrome c release
Enhanced formation of reactive oxygen species (ROS), superoxide (O(2) (·−)), and hydrogen peroxide (H(2)O(2)) may result in either apoptosis or other forms of cell death. Here, we studied the mechanisms underlying activation of the apoptotic machinery by ROS. Exposure of permeabilized HepG2 cells to...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2001
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150912/ https://www.ncbi.nlm.nih.gov/pubmed/11739410 http://dx.doi.org/10.1083/jcb.200105057 |