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VDAC-dependent permeabilization of the outer mitochondrial membrane by superoxide induces rapid and massive cytochrome c release

Enhanced formation of reactive oxygen species (ROS), superoxide (O(2) (·−)), and hydrogen peroxide (H(2)O(2)) may result in either apoptosis or other forms of cell death. Here, we studied the mechanisms underlying activation of the apoptotic machinery by ROS. Exposure of permeabilized HepG2 cells to...

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Detalles Bibliográficos
Autores principales: Madesh, Muniswamy, Hajnóczky, György
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150912/
https://www.ncbi.nlm.nih.gov/pubmed/11739410
http://dx.doi.org/10.1083/jcb.200105057

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