Heavy chain–only antibodies are spontaneously produced in light chain–deficient mice

In healthy mammals, maturation of B cells expressing heavy (H) chain immunoglobulin (Ig) without light (L) chain is prevented by chaperone association of the H chain in the endoplasmic reticulum. Camelids are an exception, expressing homodimeric IgGs, an antibody type that to date has not been found...

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Detalles Bibliográficos
Autores principales: Zou, Xiangang, Osborn, Michael J., Bolland, Daniel J., Smith, Jennifer A., Corcos, Daniel, Hamon, Maureen, Oxley, David, Hutchings, Amanda, Morgan, Geoff, Santos, Fatima, Kilshaw, Peter J., Taussig, Michael J., Corcoran, Anne E., Brüggemann, Marianne
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150980/
https://www.ncbi.nlm.nih.gov/pubmed/18086860
http://dx.doi.org/10.1084/jem.20071155

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150980/
https://www.ncbi.nlm.nih.gov/pubmed/18086860
http://dx.doi.org/10.1084/jem.20071155

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