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Chromosomal position of a V(H) gene segment determines its activation and inactivation as a substrate for V(D)J recombination
Complete IgHC gene rearrangement occurs only in B cells in a stage-specific and ordered manner. We used gene targeting to reposition a distal V(H) gene segment to a region just 5′ of the D(H) gene cluster and found its activation to be highly dependent on the chromosomal domain within which it resid...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2007
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150984/ https://www.ncbi.nlm.nih.gov/pubmed/18056289 http://dx.doi.org/10.1084/jem.20071787 |