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Chromosomal position of a V(H) gene segment determines its activation and inactivation as a substrate for V(D)J recombination

Complete IgHC gene rearrangement occurs only in B cells in a stage-specific and ordered manner. We used gene targeting to reposition a distal V(H) gene segment to a region just 5′ of the D(H) gene cluster and found its activation to be highly dependent on the chromosomal domain within which it resid...

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Detalles Bibliográficos
Autores principales:	Bates, Jamie Geier, Cado, Dragana, Nolla, Hector, Schlissel, Mark S.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2007
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150984/ https://www.ncbi.nlm.nih.gov/pubmed/18056289 http://dx.doi.org/10.1084/jem.20071787

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