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Integrating Conflicting Chemotactic Signals: The Role of Memory in Leukocyte Navigation
Leukocytes navigate through complex chemoattractant arrays, and in so doing, they must migrate from one chemoattractant source to another. By evaluating directional persistence and chemotaxis during neutrophil migration under agarose, we show that cells migrating away from a local chemoattractant, a...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
1999
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151176/ https://www.ncbi.nlm.nih.gov/pubmed/10545501 |
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author | Foxman, Ellen F. Kunkel, Eric J. Butcher, Eugene C. |
author_facet | Foxman, Ellen F. Kunkel, Eric J. Butcher, Eugene C. |
author_sort | Foxman, Ellen F. |
collection | PubMed |
description | Leukocytes navigate through complex chemoattractant arrays, and in so doing, they must migrate from one chemoattractant source to another. By evaluating directional persistence and chemotaxis during neutrophil migration under agarose, we show that cells migrating away from a local chemoattractant, against a gradient, display true chemotaxis to distant agonists, often behaving as if the local gradient were without effect. We describe two interrelated properties of migrating cells that allow this to occur. First, migrating leukocytes can integrate competing chemoattractant signals, responding as if to the vector sum of the orienting signals present. Second, migrating cells display memory of their recent environment: cells' perception of the relative strength of orienting signals is influenced by their history, so that cells prioritize newly arising or newly encountered attractants. We propose that this cellular memory, by promoting sequential chemotaxis to one attractant after another, is in fact responsible for the integration of competitive orienting signals over time, and allows combinations of chemoattractants to guide leukocytes in a step-by-step fashion to their destinations within tissues. |
format | Text |
id | pubmed-2151176 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1999 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21511762008-05-01 Integrating Conflicting Chemotactic Signals: The Role of Memory in Leukocyte Navigation Foxman, Ellen F. Kunkel, Eric J. Butcher, Eugene C. J Cell Biol Original Article Leukocytes navigate through complex chemoattractant arrays, and in so doing, they must migrate from one chemoattractant source to another. By evaluating directional persistence and chemotaxis during neutrophil migration under agarose, we show that cells migrating away from a local chemoattractant, against a gradient, display true chemotaxis to distant agonists, often behaving as if the local gradient were without effect. We describe two interrelated properties of migrating cells that allow this to occur. First, migrating leukocytes can integrate competing chemoattractant signals, responding as if to the vector sum of the orienting signals present. Second, migrating cells display memory of their recent environment: cells' perception of the relative strength of orienting signals is influenced by their history, so that cells prioritize newly arising or newly encountered attractants. We propose that this cellular memory, by promoting sequential chemotaxis to one attractant after another, is in fact responsible for the integration of competitive orienting signals over time, and allows combinations of chemoattractants to guide leukocytes in a step-by-step fashion to their destinations within tissues. The Rockefeller University Press 1999-11-01 /pmc/articles/PMC2151176/ /pubmed/10545501 Text en © 1999 The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Original Article Foxman, Ellen F. Kunkel, Eric J. Butcher, Eugene C. Integrating Conflicting Chemotactic Signals: The Role of Memory in Leukocyte Navigation |
title | Integrating Conflicting Chemotactic Signals: The Role of Memory in Leukocyte Navigation |
title_full | Integrating Conflicting Chemotactic Signals: The Role of Memory in Leukocyte Navigation |
title_fullStr | Integrating Conflicting Chemotactic Signals: The Role of Memory in Leukocyte Navigation |
title_full_unstemmed | Integrating Conflicting Chemotactic Signals: The Role of Memory in Leukocyte Navigation |
title_short | Integrating Conflicting Chemotactic Signals: The Role of Memory in Leukocyte Navigation |
title_sort | integrating conflicting chemotactic signals: the role of memory in leukocyte navigation |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151176/ https://www.ncbi.nlm.nih.gov/pubmed/10545501 |
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