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Integrating Conflicting Chemotactic Signals: The Role of Memory in Leukocyte Navigation

Leukocytes navigate through complex chemoattractant arrays, and in so doing, they must migrate from one chemoattractant source to another. By evaluating directional persistence and chemotaxis during neutrophil migration under agarose, we show that cells migrating away from a local chemoattractant, a...

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Detalles Bibliográficos
Autores principales: Foxman, Ellen F., Kunkel, Eric J., Butcher, Eugene C.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1999
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151176/
https://www.ncbi.nlm.nih.gov/pubmed/10545501
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author Foxman, Ellen F.
Kunkel, Eric J.
Butcher, Eugene C.
author_facet Foxman, Ellen F.
Kunkel, Eric J.
Butcher, Eugene C.
author_sort Foxman, Ellen F.
collection PubMed
description Leukocytes navigate through complex chemoattractant arrays, and in so doing, they must migrate from one chemoattractant source to another. By evaluating directional persistence and chemotaxis during neutrophil migration under agarose, we show that cells migrating away from a local chemoattractant, against a gradient, display true chemotaxis to distant agonists, often behaving as if the local gradient were without effect. We describe two interrelated properties of migrating cells that allow this to occur. First, migrating leukocytes can integrate competing chemoattractant signals, responding as if to the vector sum of the orienting signals present. Second, migrating cells display memory of their recent environment: cells' perception of the relative strength of orienting signals is influenced by their history, so that cells prioritize newly arising or newly encountered attractants. We propose that this cellular memory, by promoting sequential chemotaxis to one attractant after another, is in fact responsible for the integration of competitive orienting signals over time, and allows combinations of chemoattractants to guide leukocytes in a step-by-step fashion to their destinations within tissues.
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spelling pubmed-21511762008-05-01 Integrating Conflicting Chemotactic Signals: The Role of Memory in Leukocyte Navigation Foxman, Ellen F. Kunkel, Eric J. Butcher, Eugene C. J Cell Biol Original Article Leukocytes navigate through complex chemoattractant arrays, and in so doing, they must migrate from one chemoattractant source to another. By evaluating directional persistence and chemotaxis during neutrophil migration under agarose, we show that cells migrating away from a local chemoattractant, against a gradient, display true chemotaxis to distant agonists, often behaving as if the local gradient were without effect. We describe two interrelated properties of migrating cells that allow this to occur. First, migrating leukocytes can integrate competing chemoattractant signals, responding as if to the vector sum of the orienting signals present. Second, migrating cells display memory of their recent environment: cells' perception of the relative strength of orienting signals is influenced by their history, so that cells prioritize newly arising or newly encountered attractants. We propose that this cellular memory, by promoting sequential chemotaxis to one attractant after another, is in fact responsible for the integration of competitive orienting signals over time, and allows combinations of chemoattractants to guide leukocytes in a step-by-step fashion to their destinations within tissues. The Rockefeller University Press 1999-11-01 /pmc/articles/PMC2151176/ /pubmed/10545501 Text en © 1999 The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Original Article
Foxman, Ellen F.
Kunkel, Eric J.
Butcher, Eugene C.
Integrating Conflicting Chemotactic Signals: The Role of Memory in Leukocyte Navigation
title Integrating Conflicting Chemotactic Signals: The Role of Memory in Leukocyte Navigation
title_full Integrating Conflicting Chemotactic Signals: The Role of Memory in Leukocyte Navigation
title_fullStr Integrating Conflicting Chemotactic Signals: The Role of Memory in Leukocyte Navigation
title_full_unstemmed Integrating Conflicting Chemotactic Signals: The Role of Memory in Leukocyte Navigation
title_short Integrating Conflicting Chemotactic Signals: The Role of Memory in Leukocyte Navigation
title_sort integrating conflicting chemotactic signals: the role of memory in leukocyte navigation
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151176/
https://www.ncbi.nlm.nih.gov/pubmed/10545501
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