The anti-cancer drug 5-fluorouracil is metabolized by the isolated perfused rat liver and in rats into highly toxic fluoroacetate.

We report the first demonstration of the biotransformation of the anti-cancer drug 5-fluorouracil (FU) into two new metabolites, alpha-fluoro-beta-hydroxypropionic acid (FHPA) and fluoroacetate (FAC), in the isolated perfused rat liver (IPRL) and in the rat in vivo. IPRL was perfused with solutions...

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Detalles Bibliográficos
Autores principales: Arellano, M., Malet-Martino, M., Martino, R., Gires, P.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1998
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151255/
https://www.ncbi.nlm.nih.gov/pubmed/9459149

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151255/
https://www.ncbi.nlm.nih.gov/pubmed/9459149

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