A Single P-loop Glutamate Point Mutation to either Lysine or Arginine Switches the Cation–Anion Selectivity of the CNGA2 Channel

Cyclic nucleotide-gated (CNG) channels play a critical role in olfactory and visual transduction. Site-directed mutagenesis and inside-out patch-clamp recordings were used to investigate ion permeation and selectivity in two mutant homomeric rat olfactory CNGA2 channels expressed in HEK293 cells. A...

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Detalles Bibliográficos
Autores principales: Qu, Wei, Moorhouse, Andrew J., Chandra, Meenak, Pierce, Kerrie D., Lewis, Trevor M., Barry, Peter H.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151509/
https://www.ncbi.nlm.nih.gov/pubmed/16533895
http://dx.doi.org/10.1085/jgp.200509378

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151509/
https://www.ncbi.nlm.nih.gov/pubmed/16533895
http://dx.doi.org/10.1085/jgp.200509378

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