Ring of Negative Charge in BK Channels Facilitates Block by Intracellular Mg(2+) and Polyamines through Electrostatics

Intracellular Mg(2+) and natural polyamines block outward currents in BK channels in a highly voltage-dependent manner. Here we investigate the contribution of the ring of eight negatively charged residues (4 x E321/E324) at the entrance to the inner vestibule of BK channels to this block. Channels...

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Detalles Bibliográficos
Autores principales: Zhang, Yaxia, Niu, Xiaowei, Brelidze, Tinatin I., Magleby, Karl L.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151526/
https://www.ncbi.nlm.nih.gov/pubmed/16847096
http://dx.doi.org/10.1085/jgp.200609493

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151526/
https://www.ncbi.nlm.nih.gov/pubmed/16847096
http://dx.doi.org/10.1085/jgp.200609493

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