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Ring of Negative Charge in BK Channels Facilitates Block by Intracellular Mg(2+) and Polyamines through Electrostatics
Intracellular Mg(2+) and natural polyamines block outward currents in BK channels in a highly voltage-dependent manner. Here we investigate the contribution of the ring of eight negatively charged residues (4 x E321/E324) at the entrance to the inner vestibule of BK channels to this block. Channels...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2006
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151526/ https://www.ncbi.nlm.nih.gov/pubmed/16847096 http://dx.doi.org/10.1085/jgp.200609493 |