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Membrane Stretch Slows the Concerted Step prior to Opening in a Kv Channel

In the simplest model of channel mechanosensitivity, expanded states are favored by stretch. We showed previously that stretch accelerates voltage-dependent activation and slow inactivation in a Kv channel, but whether these transitions involve expansions is unknown. Thus, while voltage-gated channe...

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Detalles Bibliográficos
Autores principales: Laitko, Ulrike, Juranka, Peter F., Morris, Catherine E.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151533/
https://www.ncbi.nlm.nih.gov/pubmed/16735754
http://dx.doi.org/10.1085/jgp.200509394