Thermodynamics of CFTR Channel Gating: A Spreading Conformational Change Initiates an Irreversible Gating Cycle

CFTR is the only ABC (ATP-binding cassette) ATPase known to be an ion channel. Studies of CFTR channel function, feasible with single-molecule resolution, therefore provide a unique glimpse of ABC transporter mechanism. CFTR channel opening and closing (after regulatory-domain phosphorylation) follo...

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Detalles Bibliográficos
Autores principales: Csanády, László, Nairn, Angus C., Gadsby, David C.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151586/
https://www.ncbi.nlm.nih.gov/pubmed/17043148
http://dx.doi.org/10.1085/jgp.200609558

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151586/
https://www.ncbi.nlm.nih.gov/pubmed/17043148
http://dx.doi.org/10.1085/jgp.200609558

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