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Ca(2+)–Secretion Coupling Is Impaired in Diabetic Goto Kakizaki rats
The Goto Kakizaki (GK) rat is a widely used animal model to study defective glucose-stimulated insulin release in type-2 diabetes (T2D). As in T2D patients, the expression of several proteins involved in Ca(2+)-dependent exocytosis of insulin-containing large dense-core vesicles is dysregulated in t...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2007
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151625/ https://www.ncbi.nlm.nih.gov/pubmed/17535961 http://dx.doi.org/10.1085/jgp.200609604 |