Block of Ca(V)1.2 Channels by Gd(3+) Reveals Preopening Transitions in the Selectivity Filter

Using the lanthanide gadolinium (Gd(3+)) as a Ca(2+) replacing probe, we investigated the voltage dependence of pore blockage of Ca(V)1.2 channels. Gd(+3) reduces peak currents (tonic block) and accelerates decay of ionic current during depolarization (use-dependent block). Because diffusion of Gd(3...

Descripción completa

Detalles Bibliográficos
Autores principales: Babich, Olga, Reeves, John, Shirokov, Roman
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151628/
https://www.ncbi.nlm.nih.gov/pubmed/17535959
http://dx.doi.org/10.1085/jgp.200709733

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151628/
https://www.ncbi.nlm.nih.gov/pubmed/17535959
http://dx.doi.org/10.1085/jgp.200709733

Ejemplares similares