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Block of Ca(V)1.2 Channels by Gd(3+) Reveals Preopening Transitions in the Selectivity Filter

Using the lanthanide gadolinium (Gd(3+)) as a Ca(2+) replacing probe, we investigated the voltage dependence of pore blockage of Ca(V)1.2 channels. Gd(+3) reduces peak currents (tonic block) and accelerates decay of ionic current during depolarization (use-dependent block). Because diffusion of Gd(3...

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Detalles Bibliográficos
Autores principales:	Babich, Olga, Reeves, John, Shirokov, Roman
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2007
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151628/ https://www.ncbi.nlm.nih.gov/pubmed/17535959 http://dx.doi.org/10.1085/jgp.200709733

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