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Intracellular Ca(2+) Oscillations, a Potential Pacemaking Mechanism in Early Embryonic Heart Cells

Early (E9.5–E11.5) embryonic heart cells beat spontaneously, even though the adult pacemaking mechanisms are not yet fully established. Here we show that in isolated murine early embryonic cardiomyocytes periodic oscillations of cytosolic Ca(2+) occur and that these induce contractions. The Ca(2+) o...

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Detalles Bibliográficos
Autores principales: Sasse, Philipp, Zhang, Jianbao, Cleemann, Lars, Morad, Martin, Hescheler, Juergen, Fleischmann, Bernd K.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151640/
https://www.ncbi.nlm.nih.gov/pubmed/17664344
http://dx.doi.org/10.1085/jgp.200609575