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Acetylcholine Receptor Gating at Extracellular Transmembrane Domain Interface: the Cys-Loop and M2–M3 Linker

Acetylcholine receptor channel gating is a propagated conformational cascade that links changes in structure and function at the transmitter binding sites in the extracellular domain (ECD) with those at a “gate” in the transmembrane domain (TMD). We used Φ-value analysis to probe the relative timing...

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Detalles Bibliográficos
Autores principales: Jha, Archana, Cadugan, David J., Purohit, Prasad, Auerbach, Anthony
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151658/
https://www.ncbi.nlm.nih.gov/pubmed/18040057
http://dx.doi.org/10.1085/jgp.200709856