Orai1 Mutations Alter Ion Permeation and Ca(2+)-dependent Fast Inactivation of CRAC Channels: Evidence for Coupling of Permeation and Gating

Ca(2+) entry through store-operated Ca(2+) release-activated Ca(2+) (CRAC) channels is an essential trigger for lymphocyte activation and proliferation. The recent identification of Orai1 as a key CRAC channel pore subunit paves the way for understanding the molecular basis of Ca(2+) selectivity, io...

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Detalles Bibliográficos
Autores principales: Yamashita, Megumi, Navarro-Borelly, Laura, McNally, Beth A., Prakriya, Murali
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151669/
https://www.ncbi.nlm.nih.gov/pubmed/17968026
http://dx.doi.org/10.1085/jgp.200709872

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151669/
https://www.ncbi.nlm.nih.gov/pubmed/17968026
http://dx.doi.org/10.1085/jgp.200709872

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