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Orai1 Mutations Alter Ion Permeation and Ca(2+)-dependent Fast Inactivation of CRAC Channels: Evidence for Coupling of Permeation and Gating
Ca(2+) entry through store-operated Ca(2+) release-activated Ca(2+) (CRAC) channels is an essential trigger for lymphocyte activation and proliferation. The recent identification of Orai1 as a key CRAC channel pore subunit paves the way for understanding the molecular basis of Ca(2+) selectivity, io...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2007
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151669/ https://www.ncbi.nlm.nih.gov/pubmed/17968026 http://dx.doi.org/10.1085/jgp.200709872 |