Case report: quantification of methadone-induced respiratory depression using toxicokinetic/toxicodynamic relationships

INTRODUCTION: Methadone, the most widely delivered maintenance therapy for heroin addicts, may be responsible for life-threatening poisonings with respiratory depression. The toxicokinetics and the toxicokinetic/toxicodynamic (TK/TD) relationships of methadone enantiomers have been poorly investigat...

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Detalles Bibliográficos
Autores principales: Mégarbane, Bruno, Declèves, Xavier, Bloch, Vanessa, Bardin, Christophe, Chast, François, Baud, Frédéric J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151854/
https://www.ncbi.nlm.nih.gov/pubmed/17224045
http://dx.doi.org/10.1186/cc5150

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151854/
https://www.ncbi.nlm.nih.gov/pubmed/17224045
http://dx.doi.org/10.1186/cc5150

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