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Case report: quantification of methadone-induced respiratory depression using toxicokinetic/toxicodynamic relationships

INTRODUCTION: Methadone, the most widely delivered maintenance therapy for heroin addicts, may be responsible for life-threatening poisonings with respiratory depression. The toxicokinetics and the toxicokinetic/toxicodynamic (TK/TD) relationships of methadone enantiomers have been poorly investigat...

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Detalles Bibliográficos
Autores principales:	Mégarbane, Bruno, Declèves, Xavier, Bloch, Vanessa, Bardin, Christophe, Chast, François, Baud, Frédéric J
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2007
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151854/ https://www.ncbi.nlm.nih.gov/pubmed/17224045 http://dx.doi.org/10.1186/cc5150

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