Apoptotic Activities of Wild-Type and Alzheimer's Disease-Related Mutant Presenilins in Drosophila melanogaster

Mutant human presenilins cause early-onset familial Alzheimer's disease and render cells susceptible to apoptosis in cultured cell models. We show that loss of presenilin function in Drosophila melanogaster increases levels of apoptosis in developing tissues. Moreover, overexpression of preseni...

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Detalles Bibliográficos
Autores principales: Ye, Yihong, Fortini, Mark E.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1999
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2156122/
https://www.ncbi.nlm.nih.gov/pubmed/10491396

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2156122/
https://www.ncbi.nlm.nih.gov/pubmed/10491396

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