Cargando…

Effect of hypoxia and Beraprost sodium on human pulmonary arterial smooth muscle cell proliferation: the role of p27(kip1)

BACKGROUND: Hypoxia induces the proliferation of pulmonary arterial smooth muscle cell (PASMC) in vivo and in vitro, and prostacyclin analogues are thought to inhibit the growth of PASMC. Previous studies suggest that p27(kip1), a kind of cyclin-dependent kinase inhibitor, play an important role in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kadowaki, Maiko, Mizuno, Shiro, Demura, Yoshiki, Ameshima, Shingo, Miyamori, Isamu, Ishizaki, Takeshi
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2007
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2164950/ https://www.ncbi.nlm.nih.gov/pubmed/17974037 http://dx.doi.org/10.1186/1465-9921-8-77

Ejemplares similares

Hypoxia regulates human lung fibroblast proliferation via p53-dependent and -independent pathways
por: Mizuno, Shiro, et al.
Publicado: (2009)

Ameliorative Effect of Beraprost Sodium on Celecoxib Induced Cardiotoxicity in Rats
por: Ahmad, Shafique, et al.
Publicado: (2018)

Beraprost Sodium for Pulmonary Hypertension in Dogs: Effect on Hemodynamics and Cardiac Function
por: Suzuki, Ryohei, et al.
Publicado: (2022)

Effect of beraprost sodium on arterial stiffness in patients with type 2 diabetic nephropathy
por: Na, Ki Young, et al.
Publicado: (2013)

Effects of Beraprost Sodium on Subjective Symptoms in Diabetic Patients with Peripheral Arterial Disease
por: Yoon, Hang Seob, et al.
Publicado: (2013)

Beraprost sodium protects against chronic brain injury in aluminum-overload rats
por: Pan, Yongquan, et al.
Publicado: (2015)

Beneficial Effect of Beraprost Sodium Plus Aspirin in the Treatment of Acute Ischemic Stroke
por: Chen, Siqia, et al.
Publicado: (2017)

Investigation of Beraprost Sodium on Cardiac Function and Hemodynamics in Canine Models of Chronic Pulmonary Hypertension
por: Suzuki, Ryohei, et al.
Publicado: (2022)

Clinical efficacy and safety of beraprost sodium in the treatment of nephrotic syndrome: A meta-analysis
por: Yan, Peng, et al.
Publicado: (2023)

Catalytic asymmetric formal synthesis of beraprost
por: Kobayashi, Yusuke, et al.
Publicado: (2015)

p27(Kip1) and Ser10-phosphorylated p27(Kip1) in breast cancer: clinical significance and expression
por: Song, Wei, et al.
Publicado: (2015)

Regulation of p27(Kip1) and p57(Kip2) Functions by Natural Polyphenols
por: Russo, Gian Luigi, et al.
Publicado: (2020)

The Prostacyclin Analog Beraprost Sodium Ameliorates Characteristics of Metabolic Syndrome in Obese Zucker (Fatty) Rats
por: Sato, Nahoko, et al.
Publicado: (2010)

The effects of concomitant GERD, dyspepsia, and rhinosinusitis on asthma symptoms and FeNO in asthmatic patients taking controller medications
por: Ishizuka, Tamotsu, et al.
Publicado: (2014)

Vascular Endothelium as a Target of Beraprost Sodium and Fenofibrate for Antiatherosclerotic Therapy in Type 2 Diabetes Mellitus
por: Otsuki, Michio, et al.
Publicado: (2005)

Combination therapy with beraprost sodium and aspirin for acute ischemic stroke: a single-center retrospective study
por: Cai, De, et al.
Publicado: (2019)

Beraprost Sodium Delays the Decline of Glomerular Filtration Rate in Patients with Diabetic Nephropathy: A Retrospective Study
por: Zhou, Jingjing, et al.
Publicado: (2023)

Beraprost and Overall Survival in Cats with Chronic Kidney Disease
por: Ito, Hiroyuki, et al.
Publicado: (2023)

p27(kip1): a target for tumor therapies?
por: Nickeleit, Irina, et al.
Publicado: (2007)

p27(Kip1) regulates alpha-synuclein expression
por: Gallastegui, Edurne, et al.
Publicado: (2018)

Role of p27(Kip1) as a transcriptional regulator
por: Bachs, Oriol, et al.
Publicado: (2018)

Activation of Notch3 promotes pulmonary arterial smooth muscle cells proliferation via Hes1/p27Kip1 signaling pathway
por: Song, Yang, et al.
Publicado: (2015)

MARCKS Signaling Differentially Regulates Vascular Smooth Muscle and Endothelial Cell Proliferation through a KIS-, p27(kip1)- Dependent Mechanism
por: Yu, Dan, et al.
Publicado: (2015)

Everolimus (RAD001) inhibits the proliferation of rat vascular smooth muscle cells by up-regulating the activity of the p27/kip1 gene promoter
por: Ran, Boli, et al.
Publicado: (2016)

Short-Term Effects of Beraprost Sodium on the Markers for Cardiovascular Risk Prediction in Type 2 Diabetic Patients with Microalbuminuria
por: Choi, Yun Mi, et al.
Publicado: (2019)

Prostacyclin analog beraprost sodium efficacy in primary glomerular disease or nephrosclerosis: Analysis of the Japanese subgroup in CASSIOPEIR study
por: Kurumatani, Hajimu, et al.
Publicado: (2021)

Correction to: Beraprost Sodium Delays the Decline of Glomerular Filtration Rate in Patients with Diabetic Nephropathy: A Retrospective Study
por: Zhou, Jingjing, et al.
Publicado: (2023)

IL-7 promotes T cell proliferation through destabilization of p27(Kip1)
por: Li, Wen Qing, et al.
Publicado: (2006)

Genetic characterization of p27(kip1) and stathmin in controlling cell proliferation in vivo
por: Berton, Stefania, et al.
Publicado: (2014)

Prospective analysis of the efficacy of beraprost sodium combined with alprostadil on diabetic nephropathy and influence on rennin-angiotensin system and TNF-α
por: Xu, Xinwei, et al.
Publicado: (2020)

Beraprost sodium attenuates the development of myocardial fibrosis after myocardial infarction by regulating GSK‐3β expression in rats
por: Li, Xing‐Xing, et al.
Publicado: (2023)

Up‐regulation of p27(Kip1) Correlates Inversely with Anchorage‐independent Growth of Human Cancer Cell Lines
por: Kawada, Manabu, et al.
Publicado: (1998)

p27kip1 at the crossroad between actin and microtubule dynamics
por: Rampioni Vinciguerra, Gian Luca, et al.
Publicado: (2019)

p27(Kip1), an Intrinsically Unstructured Protein with Scaffold Properties
por: Bencivenga, Debora, et al.
Publicado: (2021)

p27(kip1) Modulates the Morphology and Phagocytic Activity of Microglia
por: Beeken, Jolien, et al.
Publicado: (2022)

Immunohistochemical Expression of p27(Kip1), p57(Kip2), Cyclin D1, Nestin, and Ki-67 in Ependymoma
por: Iqneibi, Shahad, et al.
Publicado: (2022)

p27(Kip1 )is expressed in proliferating cells in its form phosphorylated on threonine 187
por: Troncone, Giancarlo, et al.
Publicado: (2005)

A Double‐blind, Placebo‐controlled, Multicenter, Prospective, Randomized Study of Beraprost Sodium Treatment for Cats with Chronic Kidney Disease
por: Takenaka, M., et al.
Publicado: (2017)

Effect of beraprost on pulmonary hypertension due to left ventricular systolic dysfunction
por: Wang, Li, et al.
Publicado: (2019)

Prognostic role of p27(Kip1) and apoptosis in human breast cancer
por: Wu, J, et al.
Publicado: (1999)

Cannot write session to /tmp/vufind_sessions/sess_c7al7o7uu81ijehj27iu3r0nh9