P53 Inhibits α6β4 Integrin Survival Signaling by Promoting the Caspase 3–Dependent Cleavage of Akt/PKB

Although the interaction of matrix proteins with integrins is known to initiate signaling pathways that are essential for cell survival, a role for tumor suppressors in the regulation of these pathways has not been established. We demonstrate here that p53 can inhibit the survival function of integr...

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Detalles Bibliográficos
Autores principales: Bachelder, Robin E., Ribick, Mark J., Marchetti, Alessandra, Falcioni, Rita, Soddu, Silvia, Davis, Kathryn R., Mercurio, Arthur M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1999
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169339/
https://www.ncbi.nlm.nih.gov/pubmed/10579725

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169339/
https://www.ncbi.nlm.nih.gov/pubmed/10579725

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