C-Jun Activation-Dependent Tumorigenic Transformation Induced Paradoxically by Overexpression or Block of S-Adenosylmethionine Decarboxylase

All mammalian cells absolutely require polyamines (putrescine, spermidine, and spermine) for growth. Here we show that the overexpression of cDNA for S-adenosylmethionine decarboxylase (AdoMetDC), the main regulatory enzyme in the biosynthesis of higher polyamines, induces transformation of rodent f...

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Detalles Bibliográficos
Autores principales: Paasinen-Sohns, Aino, Kielosto, Mari, Kääriäinen, Essi, Eloranta, Terho, Laine, Aire, Jänne, Olli A., Birrer, Michael J., Hölttä, Erkki
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2000
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169445/
https://www.ncbi.nlm.nih.gov/pubmed/11076965

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169445/
https://www.ncbi.nlm.nih.gov/pubmed/11076965

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