Activation of GSK-3 and phosphorylation of CRMP2 in transgenic mice expressing APP intracellular domain

Amyloid precursor protein (APP), implicated in Alzheimer's disease, is a trans-membrane protein of undetermined function. APP is cleaved by γ-secretase that releases the APP intracellular domain (AICD) in the cytoplasm. In vitro studies have implicated AICD in cell signaling and transcriptional...

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Detalles Bibliográficos
Autores principales: Ryan, Kathleen A., Pimplikar, Sanjay W.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171208/
https://www.ncbi.nlm.nih.gov/pubmed/16230462
http://dx.doi.org/10.1083/jcb.200505078

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171208/
https://www.ncbi.nlm.nih.gov/pubmed/16230462
http://dx.doi.org/10.1083/jcb.200505078

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