Cdc25B cooperates with Cdc25A to induce mitosis but has a unique role in activating cyclin B1–Cdk1 at the centrosome

Cdc25 phosphatases are essential for the activation of mitotic cyclin–Cdks, but the precise roles of the three mammalian isoforms (A, B, and C) are unclear. Using RNA interference to reduce the expression of each Cdc25 isoform in HeLa and HEK293 cells, we observed that Cdc25A and -B are both needed...

Descripción completa

Detalles Bibliográficos
Autores principales: Lindqvist, Arne, Källström, Helena, Lundgren, Andreas, Barsoum, Emad, Rosenthal, Christina Karlsson
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171226/
https://www.ncbi.nlm.nih.gov/pubmed/16216921
http://dx.doi.org/10.1083/jcb.200503066

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171226/
https://www.ncbi.nlm.nih.gov/pubmed/16216921
http://dx.doi.org/10.1083/jcb.200503066

Ejemplares similares