Terminating Wnt signals: a novel nuclear export mechanism targets activated β-catenin

Nuclear targeting of β-catenin is an obligatory step in Wnt signal transduction, but the factors that control import and export remain to be clarified. In this issue, Hendriksen et al. (p. 785) show that the RanBP3 export factor antagonizes β-catenin/T cell factor (TCF) transcription by targeting th...

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Detalles Bibliográficos
Autores principales: Thorne, Meghan E., Gottardi, Cara J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171287/
https://www.ncbi.nlm.nih.gov/pubmed/16314432
http://dx.doi.org/10.1083/jcb.200510127
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author Thorne, Meghan E.
Gottardi, Cara J.
author_facet Thorne, Meghan E.
Gottardi, Cara J.
author_sort Thorne, Meghan E.
collection PubMed
description Nuclear targeting of β-catenin is an obligatory step in Wnt signal transduction, but the factors that control import and export remain to be clarified. In this issue, Hendriksen et al. (p. 785) show that the RanBP3 export factor antagonizes β-catenin/T cell factor (TCF) transcription by targeting the signaling-competent form of β-catenin. We speculate that cells may use multiple export mechanisms to inhibit β-catenin signaling in different ways.
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spelling pubmed-21712872008-03-05 Terminating Wnt signals: a novel nuclear export mechanism targets activated β-catenin Thorne, Meghan E. Gottardi, Cara J. J Cell Biol Reviews Nuclear targeting of β-catenin is an obligatory step in Wnt signal transduction, but the factors that control import and export remain to be clarified. In this issue, Hendriksen et al. (p. 785) show that the RanBP3 export factor antagonizes β-catenin/T cell factor (TCF) transcription by targeting the signaling-competent form of β-catenin. We speculate that cells may use multiple export mechanisms to inhibit β-catenin signaling in different ways. The Rockefeller University Press 2005-12-05 /pmc/articles/PMC2171287/ /pubmed/16314432 http://dx.doi.org/10.1083/jcb.200510127 Text en Copyright © 2005, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Reviews
Thorne, Meghan E.
Gottardi, Cara J.
Terminating Wnt signals: a novel nuclear export mechanism targets activated β-catenin
title Terminating Wnt signals: a novel nuclear export mechanism targets activated β-catenin
title_full Terminating Wnt signals: a novel nuclear export mechanism targets activated β-catenin
title_fullStr Terminating Wnt signals: a novel nuclear export mechanism targets activated β-catenin
title_full_unstemmed Terminating Wnt signals: a novel nuclear export mechanism targets activated β-catenin
title_short Terminating Wnt signals: a novel nuclear export mechanism targets activated β-catenin
title_sort terminating wnt signals: a novel nuclear export mechanism targets activated β-catenin
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171287/
https://www.ncbi.nlm.nih.gov/pubmed/16314432
http://dx.doi.org/10.1083/jcb.200510127
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AT gottardicaraj terminatingwntsignalsanovelnuclearexportmechanismtargetsactivatedbcatenin

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