Cargando…

Reduced Apaf-1 levels in cardiomyocytes engage strict regulation of apoptosis by endogenous XIAP

Overexpression studies have identified X-linked inhibitor of apoptosis protein (XIAP) as a potent inhibitor of caspases. However, the exact function of endogenous XIAP in regulating mammalian apoptosis is less clear. Endogenous XIAP strictly regulates cytochrome c–dependent caspase activation in sym...

Descripción completa

Detalles Bibliográficos
Autores principales:	Potts, Malia B., Vaughn, Allyson E., McDonough, Holly, Patterson, Cam, Deshmukh, Mohanish
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2005
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171313/ https://www.ncbi.nlm.nih.gov/pubmed/16344307 http://dx.doi.org/10.1083/jcb.200504082

Ejemplares similares

Critical function of endogenous XIAP in regulating caspase activation during sympathetic neuronal apoptosis
por: Potts, Patrick Ryan, et al.
Publicado: (2003)

Skeletal Muscle Differentiation Evokes Endogenous XIAP to Restrict the Apoptotic Pathway
por: Smith, Michelle I., et al.
Publicado: (2009)

Decreased apoptosome activity with neuronal differentiation sets the threshold for strict IAP regulation of apoptosis
por: Wright, Kevin M., et al.
Publicado: (2004)

Glucose Metabolism Inhibits Apoptosis in Neurons and Cancer Cells by Redox Inactivation of Cytochrome c
por: Vaughn, Allyson E., et al.
Publicado: (2008)

Chromatin modification of Apaf-1 restricts the apoptotic pathway in mature neurons
por: Wright, Kevin M., et al.
Publicado: (2007)

Muscle ring finger protein-1 inhibits PKCε activation and prevents cardiomyocyte hypertrophy
por: Arya, Ranjana, et al.
Publicado: (2004)

Apaf1 inhibition promotes cell recovery from apoptosis
por: Gortat, Anna, et al.
Publicado: (2015)

Cell differentiation: reciprocal regulation of Apaf-1 and the inhibitor of apoptosis proteins
por: Lindholm, Dan, et al.
Publicado: (2004)

Ehrlichia Notch signaling induction promotes XIAP stability and inhibits apoptosis
por: Patterson, LaNisha L., et al.
Publicado: (2023)

AB268. Down-regulation XIAP expression enhances the sensitivity of RCC cells to apoptosis, but the basal expression of XIAP in apoptosis is stable
por: Yang, Wenzheng, et al.
Publicado: (2016)

MicroRNA-186-5p is expressed highly in ethanol-induced cardiomyocytes and regulates apoptosis via the target gene XIAP
por: Liu, Ye, et al.
Publicado: (2019)

High expression of APAF-1 elevates erythroid apoptosis in iron overload myelodysplastic syndrome
por: Gu, Shucheng, et al.
Publicado: (2013)

EMC6 regulates acinar apoptosis via APAF1 in acute and chronic pancreatitis
por: Tan, Jie-hui, et al.
Publicado: (2020)

Cdyl2-60aa encoded by CircCDYL2 accelerates cardiomyocyte death by blocking APAF1 ubiquitination in rats
por: Deng, Yunfei, et al.
Publicado: (2023)

Starfish Apaf-1 activates effector caspase-3/9 upon apoptosis of aged eggs
por: Tamura, Ritsuko, et al.
Publicado: (2018)

miR-937 regulates the proliferation and apoptosis via targeting APAF1 in breast cancer
por: Fang, Huiying, et al.
Publicado: (2019)

Dynein links engulfment and execution of apoptosis via CED-4/Apaf1 in C. elegans
por: Harders, Rikke Hindsgaul, et al.
Publicado: (2018)

Endogenous Proliferation after Spinal Cord Injury in Animal Models
por: McDonough, Ashley, et al.
Publicado: (2012)

The X-linked inhibitor of apoptosis protein (XIAP) is up-regulated in metastatic melanoma, and XIAP cleavage by Phenoxodiol is associated with Carboplatin sensitization
por: Kluger, Harriet M, et al.
Publicado: (2007)

XIAP impairs Smac release from the mitochondria during apoptosis
por: Flanagan, L, et al.
Publicado: (2010)

XIAP underlies apoptosis resistance of renal cell carcinoma cells
por: Yang, Wen Zheng, et al.
Publicado: (2018)

Nicorandil inhibits cardiomyocyte apoptosis and improves cardiac function by suppressing the HtrA2/XIAP/PARP signaling after coronary microembolization in rats
por: Zheng, Jing, et al.
Publicado: (2021)

Reduced Apaf-1 expression in human cutaneous melanomas
por: Dai, D L, et al.
Publicado: (2004)

Co-transduction of Apaf-1 and caspase-9 highly enhances p53-mediated apoptosis in gliomas
por: Shinoura, N, et al.
Publicado: (2002)

Atrogin-1 inhibits Akt-dependent cardiac hypertrophy in mice via ubiquitin-dependent coactivation of Forkhead proteins
por: Li, Hui-Hua, et al.
Publicado: (2022)

Depletion of PHD3 Protects Heart from Ischemia/Reperfusion Injury by Inhibiting Cardiomyocyte Apoptosis
por: Xie, Liang, et al.
Publicado: (2015)

The long noncoding RNA XIAP-AS1 promotes XIAP transcription by XIAP-AS1 interacting with Sp1 in gastric cancer cells
por: Cai, Jun, et al.
Publicado: (2017)

Computational Evaluation of the Strict Master and Random Template Models of Endogenous Retrovirus Evolution
por: Nascimento, Fabrícia F., et al.
Publicado: (2016)

Cannabidiol promotes apoptosis via regulation of XIAP/Smac in gastric cancer
por: Jeong, Soyeon, et al.
Publicado: (2019)

An epistatic effect of apaf-1 and caspase-9 on chlamydial infection
por: Rahman, Mohd. Akhlakur, et al.
Publicado: (2015)

Aberrant Methylation-Mediated Suppression of APAF1 in Myelodysplastic Syndrome
por: Zaker, Farhad, et al.
Publicado: (2017)

In silico approach to the analysis of SNPs in the human APAF1 gene
por: KAMAN, Tuğba, et al.
Publicado: (2019)

Allele Frequency of APAF1 Mutation in Holstein Cattle in Brazil
por: Albertino, Lukas Garrido, et al.
Publicado: (2022)

Lack of X-linked inhibitor of apoptosis protein leads to increased apoptosis and tissue loss following neonatal brain injury
por: West, Tim, et al.
Publicado: (2009)

Knockdown of endogenous RNF4 exacerbates ischaemia‐induced cardiomyocyte apoptosis in mice
por: Qiu, Fang, et al.
Publicado: (2020)

Diablo Promotes Apoptosis by Removing Miha/Xiap from Processed Caspase 9
por: Ekert, Paul G., et al.
Publicado: (2001)

MicroRNA-24 regulates XIAP to reduce the apoptosis threshold in cancer cells
por: Xie, Yili, et al.
Publicado: (2012)

XIAP inhibits mature Smac-induced apoptosis by degrading it through ubiquitination in NSCLC
por: Qin, Sida, et al.
Publicado: (2016)

Combined inhibition of XIAP and autophagy induces apoptosis and differentiation in acute myeloid leukaemia
por: Huang, Ziyang, et al.
Publicado: (2023)

Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die
por: Ekert, Paul G., et al.
Publicado: (2004)

Cannot write session to /tmp/vufind_sessions/sess_9r662i8h5hvv397avqg53ueooq