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Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor–κB activation in muramyl dipeptide recognition

Nucleotide oligomerization domain (NOD) 2 functions as a mammalian cytosolic pathogen recognition molecule, and mutant forms have been genetically linked to Crohn's disease (CD). NOD2 associates with the caspase activation and recruitment domain of RIP-like interacting caspase-like apoptosis re...

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Detalles Bibliográficos
Autores principales: Barnich, Nicolas, Aguirre, Jose E., Reinecker, Hans-Christian, Xavier, Ramnik, Podolsky, Daniel K.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171381/
https://www.ncbi.nlm.nih.gov/pubmed/15998797
http://dx.doi.org/10.1083/jcb.200502153