LIS1 RNA interference blocks neural stem cell division, morphogenesis, and motility at multiple stages

Mutations in the human LIS1 gene cause the smooth brain disease classical lissencephaly. To understand the underlying mechanisms, we conducted in situ live cell imaging analysis of LIS1 function throughout the entire radial migration pathway. In utero electroporation of LIS1 small interference RNA a...

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Detalles Bibliográficos
Autores principales: Tsai, Jin-Wu, Chen, Yu, Kriegstein, Arnold R., Vallee, Richard B.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171430/
https://www.ncbi.nlm.nih.gov/pubmed/16144905
http://dx.doi.org/10.1083/jcb.200505166

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171430/
https://www.ncbi.nlm.nih.gov/pubmed/16144905
http://dx.doi.org/10.1083/jcb.200505166

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