p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

Autophagic degradation of ubiquitinated protein aggregates is important for cell survival, but it is not known how the autophagic machinery recognizes such aggregates. In this study, we report that polymerization of the polyubiquitin-binding protein p62/SQSTM1 yields protein bodies that either resid...

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Detalles Bibliográficos
Autores principales: Bjørkøy, Geir, Lamark, Trond, Brech, Andreas, Outzen, Heidi, Perander, Maria, Øvervatn, Aud, Stenmark, Harald, Johansen, Terje
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171557/
https://www.ncbi.nlm.nih.gov/pubmed/16286508
http://dx.doi.org/10.1083/jcb.200507002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171557/
https://www.ncbi.nlm.nih.gov/pubmed/16286508
http://dx.doi.org/10.1083/jcb.200507002

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