BACE overexpression alters the subcellular processing of APP and inhibits Aβ deposition in vivo

Introducing mutations within the amyloid precursor protein (APP) that affect β- and γ-secretase cleavages results in amyloid plaque formation in vivo. However, the relationship between β-amyloid deposition and the subcellular site of Aβ production is unknown. To determine the effect of increasing β-...

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Detalles Bibliográficos
Autores principales: Lee, Edward B., Zhang, Bin, Liu, Kangning, Greenbaum, Eric A., Doms, Robert W., Trojanowski, John Q., Lee, Virginia M.-Y.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171598/
https://www.ncbi.nlm.nih.gov/pubmed/15642747
http://dx.doi.org/10.1083/jcb.200407070

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171598/
https://www.ncbi.nlm.nih.gov/pubmed/15642747
http://dx.doi.org/10.1083/jcb.200407070

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