p107 inhibits G1 to S phase progression by down-regulating expression of the F-box protein Skp2

Cell cycle progression is negatively regulated by the pocket proteins pRb, p107, and p130. However, the mechanisms responsible for this inhibition are not fully understood. Here, we show that overexpression of p107 in fibroblasts inhibits Cdk2 activation and delays S phase entry. The inhibition of C...

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Detalles Bibliográficos
Autores principales: Rodier, Geneviève, Makris, Constantin, Coulombe, Philippe, Scime, Anthony, Nakayama, Keiko, Nakayama, Keiichi I., Meloche, Sylvain
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171673/
https://www.ncbi.nlm.nih.gov/pubmed/15631990
http://dx.doi.org/10.1083/jcb.200404146

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171673/
https://www.ncbi.nlm.nih.gov/pubmed/15631990
http://dx.doi.org/10.1083/jcb.200404146

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