Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity

Huntington's disease (HD) is a neurodegenerative disorder caused by an expanded polyglutamine (polyQ) tract in the huntingtin (htt) protein. Mutant htt toxicity is exposed after htt cleavage by caspases and other proteases release NH(2)-terminal fragments containing the polyQ expansion. Here, w...

Descripción completa

Detalles Bibliográficos
Autores principales: Luo, Shouqing, Vacher, Coralie, Davies, Janet E., Rubinsztein, David C.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171695/
https://www.ncbi.nlm.nih.gov/pubmed/15911879
http://dx.doi.org/10.1083/jcb.200412071

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171695/
https://www.ncbi.nlm.nih.gov/pubmed/15911879
http://dx.doi.org/10.1083/jcb.200412071

Ejemplares similares