Linking axonal degeneration to microtubule remodeling by Spastin-mediated microtubule severing

Mutations in the AAA adenosine triphosphatase (ATPase) Spastin (SPG4) cause an autosomal dominant form of hereditary spastic paraplegia, which is a retrograde axonopathy primarily characterized pathologically by the degeneration of long spinal neurons in the corticospinal tracts and the dorsal colum...

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Detalles Bibliográficos
Autores principales: Evans, Katia J., Gomes, Edgar R., Reisenweber, Steven M., Gundersen, Gregg G., Lauring, Brett P.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171748/
https://www.ncbi.nlm.nih.gov/pubmed/15716377
http://dx.doi.org/10.1083/jcb.200409058

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171748/
https://www.ncbi.nlm.nih.gov/pubmed/15716377
http://dx.doi.org/10.1083/jcb.200409058

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