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Inhibition of endothelial cell migration by thrombospondin-1 type-1 repeats is mediated by β(1) integrins
The anti-angiogenic effect of thrombospondin-1 has been shown to be mediated through binding of the type-1 repeat (TSR) domain to the CD36 transmembrane receptor. We now report that the TSR domain can inhibit VEGF-induced migration in human umbilical vein endothelial cells (HUVEC), cells that lack C...
Autores principales: | Short, Sarah M., Derrien, Alexandrine, Narsimhan, Radha P., Lawler, Jack, Ingber, Donald E., Zetter, Bruce R. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2005
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171765/ https://www.ncbi.nlm.nih.gov/pubmed/15716381 http://dx.doi.org/10.1083/jcb.200407060 |
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