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Inhibition of NGF deprivation–induced death by low oxygen involves suppression of BIM(EL) and activation of HIF-1

Changes in O(2) tension can significantly impact cell survival, yet the mechanisms underlying these effects are not well understood. Here, we report that maintaining sympathetic neurons under low O(2) inhibits apoptosis caused by NGF deprivation. Low O(2) exposure blocked cytochrome c release after...

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Detalles Bibliográficos
Autores principales: Xie, Liang, Johnson, Randall S., Freeman, Robert S.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171791/
https://www.ncbi.nlm.nih.gov/pubmed/15767462
http://dx.doi.org/10.1083/jcb.200407079