Cargando…

Three-dimensional EM structure of the ectodomain of integrin αVβ3 in a complex with fibronectin

Integrins are αβ heterodimeric cell surface receptors that mediate transmembrane signaling by binding extracellular and cytoplasmic ligands. The ectodomain of integrin αVβ3 crystallizes in a bent, genuflexed conformation considered to be inactive (unable to bind physiological ligands in solution) un...

Descripción completa

Detalles Bibliográficos
Autores principales:	Adair, Brian D., Xiong, Jian-Ping, Maddock, Catherine, Goodman, Simon L., Arnaout, M. Amin, Yeager, Mark
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2005
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171847/ https://www.ncbi.nlm.nih.gov/pubmed/15795319 http://dx.doi.org/10.1083/jcb.200410068

Ejemplares similares

Cryo-EM structures of full-length integrin αIIbβ3 in native lipids
por: Adair, Brian D., et al.
Publicado: (2023)

Crystal structure of the complete integrin αVβ3 ectodomain plus an α/β transmembrane fragment
por: Xiong, Jian-Ping, et al.
Publicado: (2009)

EM Structure of the Ectodomain of Integrin CD11b/CD18 and Localization of Its Ligand-Binding Site Relative to the Plasma Membrane
por: Adair, Brian D., et al.
Publicado: (2013)

Structural basis for pure antagonism of integrin αVβ3 by a high affinity form of fibronectin
por: Van Agthoven, Johannes F., et al.
Publicado: (2014)

Crystal structure of α5β1 integrin ectodomain: Atomic details of the fibronectin receptor
por: Nagae, Masamichi, et al.
Publicado: (2012)

αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin
por: Bharadwaj, Mitasha, et al.
Publicado: (2017)

Distinct Binding Interactions of α(5)β(1)-Integrin and Proteoglycans with Fibronectin
por: Kennelly, Thomas M., et al.
Publicado: (2019)

Structural insights into integrin α(5)β(1) opening by fibronectin ligand
por: Schumacher, Stephanie, et al.
Publicado: (2021)

Platelets drive fibronectin fibrillogenesis using integrin αIIbβ3
por: Lickert, Sebastian, et al.
Publicado: (2022)

The syndecan-1 ectodomain regulates α(v)β(3) integrin activity in human mammary carcinoma cells
por: Beauvais, DeannaLee M., et al.
Publicado: (2004)

Biology and structure of leukocyte β (2 )integrins and their role in inflammation
por: Arnaout, M. Amin
Publicado: (2016)

Clinicopathological and prognostic values of fibronectin and integrin αvβ3 expression in primary osteosarcoma
por: Shi, Kai, et al.
Publicado: (2019)

Integrin Dynamics and Matrix Assembly: Tensin-Dependent Translocation of α(5)β(1) Integrins Promotes Early Fibronectin Fibrillogenesis
por: Pankov, Roumen, et al.
Publicado: (2000)

Latent effects of fibronectin, α5β1 integrin, αVβ5 integrin and the cytoskeleton regulate pancreatic carcinoma cell IL-8 secretion
por: Lowrie, A G, et al.
Publicado: (2004)

The fibronectin-binding integrins α5β1 and αvβ3 differentially modulate RhoA–GTP loading, organization of cell matrix adhesions, and fibronectin fibrillogenesis
por: Danen, Erik H.J., et al.
Publicado: (2002)

Cryo-EM structure of the αvβ8 integrin reveals a mechanism for stabilizing integrin extension
por: Cormier, Anthony, et al.
Publicado: (2018)

Binding of ZO-1 to α5β1 integrins regulates the mechanical properties of α5β1–fibronectin links
por: González-Tarragó, Víctor, et al.
Publicado: (2017)

α5β1 Integrin-Mediated Adhesion to Fibronectin Is Required for Axis Elongation and Somitogenesis in Mice
por: Girós, Amparo, et al.
Publicado: (2011)

Integrin α5β1, the Fibronectin Receptor, as a Pertinent Therapeutic Target in Solid Tumors
por: Schaffner, Florence, et al.
Publicado: (2013)

Dynamics of integrin α5β1, fibronectin, and their complex reveal sites of interaction and conformational change
por: Su, Yang, et al.
Publicado: (2022)

Cryo-EM structure of the complete and ligand-saturated insulin receptor ectodomain
por: Gutmann, Theresia, et al.
Publicado: (2019)

Expression of fibronectin, fibronectin isoforms and integrin receptors in melanocytic lesions.
por: Natali, P. G., et al.
Publicado: (1995)

Syndecan-1-Induced ECM Fiber Alignment Requires Integrin αvβ3 and Syndecan-1 Ectodomain and Heparan Sulfate Chains
por: Yang, Ning, et al.
Publicado: (2016)

Substrate engagement of integrins α(5)β(1) and α(v)β(3) is necessary, but not sufficient, for high directional persistence in migration on fibronectin
por: Missirlis, Dimitris, et al.
Publicado: (2016)

Interaction between Fibronectin and β1 Integrin Is Essential for Tooth Development
por: Saito, Kan, et al.
Publicado: (2015)

Participation of Integrin α5β1 in the Fibronectin-Mediated Adherence of Enteroaggregative Escherichia coli to Intestinal Cells
por: Izquierdo, Mariana, et al.
Publicado: (2014)

Genetic abrogation of the fibronectin-α5β1 integrin interaction in articular cartilage aggravates osteoarthritis in mice
por: Almonte-Becerril, Maylin, et al.
Publicado: (2018)

Fibronectin is a good catch for integrin
por: Short, Ben
Publicado: (2009)

Fibronectin‐Mediated Inflammatory Signaling Through Integrin α5 in Vascular Remodeling
por: Budatha, Madhusudhan, et al.
Publicado: (2021)

PPFIA1 drives active α5β1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis
por: Mana, Giulia, et al.
Publicado: (2016)

Cryo-EM structure of the prefusion state of canine distemper virus fusion protein ectodomain
por: Kalbermatter, David, et al.
Publicado: (2020)

Integrin-α9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis
por: Bazigou, Eleni, et al.
Publicado: (2009)

Regulatory roles of fibronectin and integrin α5 in reorganization of the actin cytoskeleton and completion of adipogenesis
por: Uetaki, Megumi, et al.
Publicado: (2022)

Allosteric Regulation of Fibronectin/α(5)β(1) Interaction by Fibronectin-Binding MSCRAMMs
por: Liang, Xiaowen, et al.
Publicado: (2016)

α2 Integrin-Dependent Suppression of Pancreatic Adenocarcinoma Cell Invasion Involves Ectodomain Regulation of Kallikrein-Related Peptidase-5
por: Lee, Chia-Yao, et al.
Publicado: (2011)

Ligand independent activation of c-Met by fibronectin and α(5)β(1)-integrin regulates ovarian cancer invasion and metastasis
por: Mitra, AK, et al.
Publicado: (2010)

α5β1 Integrin-Fibronectin Interactions Specify Liquid to Solid Phase Transition of 3D Cellular Aggregates
por: Caicedo-Carvajal, Carlos E., et al.
Publicado: (2010)

α5β1-Integrin promotes tension-dependent mammary epithelial cell invasion by engaging the fibronectin synergy site
por: Miroshnikova, Y. A., et al.
Publicado: (2017)

Collective cancer cell invasion in contact with fibroblasts through integrin‐α5β1/fibronectin interaction in collagen matrix
por: Miyazaki, Kaoru, et al.
Publicado: (2020)

The interactions between integrin α(5)β(1) of liver cancer cells and fibronectin of fibroblasts promote tumor growth and angiogenesis
por: Peng, Zheng, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_uh0nu39o5p9205livj3qjfsmc5