Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2

The Tie1 receptor tyrosine kinase was isolated over a decade ago, but so far no ligand has been found to activate this receptor. Here, we have examined the potential of angiopoietins, ligands for the related Tie2 receptor, to mediate Tie1 activation. We show that a soluble Ang1 chimeric protein, COM...

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Detalles Bibliográficos
Autores principales: Saharinen, Pipsa, Kerkelä, Katja, Ekman, Niklas, Marron, Marie, Brindle, Nicholas, Lee, Gyun Min, Augustin, Hellmut, Koh, Gou Young, Alitalo, Kari
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171878/
https://www.ncbi.nlm.nih.gov/pubmed/15851516
http://dx.doi.org/10.1083/jcb.200411105

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171878/
https://www.ncbi.nlm.nih.gov/pubmed/15851516
http://dx.doi.org/10.1083/jcb.200411105

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