Phosphorylation of p66Shc and forkhead proteins mediates Aβ toxicity

Excessive accumulation of amyloid β-peptide (Aβ) plays an early and critical role in synapse and neuronal loss in Alzheimer's Disease (AD). Increased oxidative stress is one of the mechanisms whereby Aβ induces neuronal death. Given the lessened susceptibility to oxidative stress exhibited by m...

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Detalles Bibliográficos
Autores principales: Smith, Wanli W., Norton, Darrell D., Gorospe, Myriam, Jiang, Haibing, Nemoto, Shino, Holbrook, Nikki J., Finkel, Toren, Kusiak, John W.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171879/
https://www.ncbi.nlm.nih.gov/pubmed/15837797
http://dx.doi.org/10.1083/jcb.200410041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171879/
https://www.ncbi.nlm.nih.gov/pubmed/15837797
http://dx.doi.org/10.1083/jcb.200410041

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