Apaf-1 and caspase-9 do not act as tumor suppressors in myc-induced lymphomagenesis or mouse embryo fibroblast transformation

Based on experiments with cultured fibroblasts, the apoptosis regulators caspase-9 and Apaf-1 are hypothesized to function as tumor suppressors. To investigate their in vivo role in lymphomagenesis, an IgH enhancer-driven c-myc transgene was crossed onto Apaf-1(−/−) and caspase-9(−/−) mice. Due to p...

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Detalles Bibliográficos
Autores principales: Scott, Clare L., Schuler, Martin, Marsden, Vanessa S., Egle, Alex, Pellegrini, Marc, Nesic, Dobrila, Gerondakis, Steve, Nutt, Stephen L., Green, Douglas R., Strasser, Andreas
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171953/
https://www.ncbi.nlm.nih.gov/pubmed/14709542
http://dx.doi.org/10.1083/jcb.200310041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171953/
https://www.ncbi.nlm.nih.gov/pubmed/14709542
http://dx.doi.org/10.1083/jcb.200310041

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