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Misfolded proteins are sorted by a sequential checkpoint mechanism of ER quality control
Misfolded proteins retained in the endoplasmic reticulum (ER) are degraded by the ER-associated degradation pathway. The mechanisms used to sort them from correctly folded proteins remain unclear. Analysis of substrates with defined folded and misfolded domains has revealed a system of sequential ch...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2004
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172089/ https://www.ncbi.nlm.nih.gov/pubmed/15078901 http://dx.doi.org/10.1083/jcb.200309132 |