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Myotubes differentiate optimally on substrates with tissue-like stiffness: pathological implications for soft or stiff microenvironments

Contractile myocytes provide a test of the hypothesis that cells sense their mechanical as well as molecular microenvironment, altering expression, organization, and/or morphology accordingly. Here, myoblasts were cultured on collagen strips attached to glass or polymer gels of varied elasticity. Su...

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Detalles Bibliográficos
Autores principales: Engler, Adam J., Griffin, Maureen A., Sen, Shamik, Bönnemann, Carsten G., Sweeney, H. Lee, Discher, Dennis E.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172122/
https://www.ncbi.nlm.nih.gov/pubmed/15364962
http://dx.doi.org/10.1083/jcb.200405004