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Myotubes differentiate optimally on substrates with tissue-like stiffness: pathological implications for soft or stiff microenvironments
Contractile myocytes provide a test of the hypothesis that cells sense their mechanical as well as molecular microenvironment, altering expression, organization, and/or morphology accordingly. Here, myoblasts were cultured on collagen strips attached to glass or polymer gels of varied elasticity. Su...
Autores principales: | Engler, Adam J., Griffin, Maureen A., Sen, Shamik, Bönnemann, Carsten G., Sweeney, H. Lee, Discher, Dennis E. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2004
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172122/ https://www.ncbi.nlm.nih.gov/pubmed/15364962 http://dx.doi.org/10.1083/jcb.200405004 |
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